Senior Information Security Engineer

Senior Information Security Engineer

Location: Remote (United States)

Type of Role

Full-Time

Overview

An organization is seeking a Senior Information Security Engineer to serve as a senior technical leader within its Information Security team. As one of the nation's leading clinical genetic testing laboratories, the organization safeguards some of the most sensitive data that exists — patient genomic and health information — and this role is critical to protecting it. Reporting to the Director of Information Security, the Senior Information Security Engineer designs, implements, and operates the security controls that protect systems, networks, endpoints, and cloud environments. This role leads key operational security initiatives — including managed detection and response (MDR/SIEM), privileged access management, vulnerability management, and Zero Trust — and provides technical mentorship to other engineers. Scope may evolve as organizational needs change.

Key Responsibilities

• Lead and operate organizational detection and response capabilities, including SIEM/MDR, EDR/XDR, and SOAR (e.g., CrowdStrike or Microsoft Sentinel), tuning detections with organization-specific policies and response actions.
• Establish and mature a centralized, risk-based vulnerability management program with enforced patch SLAs, secure configuration baselines, and remediation of penetration test findings.
• Design and implement identity and access security controls, including Privileged Access Management (PAM), Just-in-Time (JIT) access, MFA, SSO, Conditional Access, and least-privilege principles.
• Advance the Zero Trust roadmap across identity, endpoints, networks, cloud, and data.
• Respond to and investigate security incidents end to end — detection, containment, investigation, and recovery — in line with the incident response playbook, and lead post-incident reviews.
• Implement and manage data protection controls for PHI/PII, including auto-classification and DLP (e.g., Microsoft Purview) across endpoints and cloud services.
• Collaborate with IT, Privacy, Compliance, and application teams to embed security best practices into system designs, cloud deployments, and the SDLC.

Required Experience & Skills

• Bachelor's degree in Computer Science, Cybersecurity, Information Technology, or a related field — or an equivalent combination of education and experience.
• Minimum of 6–8 years of experience in information security engineering, security operations, or a related discipline.
• Hands-on expertise with SIEM/MDR and EDR platforms (e.g., CrowdStrike, Microsoft Sentinel) and security event monitoring, triage, and tuning.
• Strong knowledge of network security, firewalls, IDS/IPS, cryptography, authentication, and authorization principles.
• Experience with vulnerability management, penetration test remediation, incident response, and endpoint/OS hardening.
• Working knowledge of cloud security (Azure and/or AWS) and identity platforms (SSO, MFA, conditional access).
• Understanding of compliance frameworks and regulations relevant to healthcare data, including HIPAA, HITRUST, NIST, and GDPR.
• Excellent written and verbal communication skills, with the ability to convey complex security concepts to technical and non-technical stakeholders.

Nice to Have

• Advanced certifications such as CISSP, CISM, GCIA, GCIH, or a cloud security specialty (e.g., Azure/AWS Security).
• Experience with privileged access management (PAM), SOAR, and Zero Trust architectures.
• Familiarity with data loss prevention (e.g., Microsoft Purview) and data classification programs.
• Prior experience in a healthcare, clinical laboratory, or other regulated (HIPAA/PHI) environment.