Computational Scientist

Russell Tobin is supporting a leading biotechnology organization with an onsite contract opening for a Computational Scientist in South San Francisco, CA.

This role will focus on analyzing large-scale multimodal perturbation datasets, training and evaluating deep learning models, and understanding how different datasets contribute to model performance and learning.

Responsibilities

• Train and evaluate deep learning models using large-scale multimodal perturbation datasets.
• Design and execute controlled train/test split experiments to assess the impact of different dataset components on model performance.
• Evaluate model outputs and performance against experimental data.
• Analyze complex biological datasets using statistical and computational methods.
• Develop reproducible, well-documented analysis workflows using scientific Python tools.
• Execute computational experiments on SLURM clusters and utilize established analysis codebases and computing resources.
• Collaborate with project leads and research teams to deliver defined project milestones and analytical outcomes.

Requirements

• PhD in a computational discipline or equivalent research experience.
• Preferred backgrounds include Computational Biology, Computational Sciences, Statistics, or Machine Learning.
• Hands-on experience training and evaluating deep learning models using PyTorch.
• Experience designing and executing controlled train/test split experiments.
• Experience working with SLURM clusters and high-performance computing environments.
• Strong applied statistics and data analysis skills.
• Proficiency in Python, including NumPy, Pandas, and Scanpy/AnnData.
• Experience analyzing biological or multimodal datasets is highly desirable.
• Strong scientific documentation, reproducible analysis, and problem-solving skills.

Preferred Qualifications

• Experience with single-cell transcriptomics
• Experience with analysis of CRISPR perturbation screens (perturb-seq or similar).
• Familiarity with representation learning
• Familiarity with image analysis

Additional Details

• Location model: South San Francisco, CA 94080 (Onsite)
• Shift: Mon to Fri 8hrs/day, 40hrs/week
• Position Type: 12-month contract (potential to extend)
• Pay range approved: $50/hr - $54.50/hr (depending on experience)

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